Nanofibrous Barrier Membrane

Periodontal disease is a major public oral health problem; nearly 50% of adults in the U.S. have some form of periodontitis. Regeneration of lost periodontal tissues requires the use of a barrier membrane device to prevent soft-tissue invasion into the defect and guide the bone regeneration process.

Matregenix developed a patent pending nanofibrous barrier membrane that will potentially provide a more convenient armamentarium for periodontal regenerative therapy. The ideal material for a barrier membrane would simultaneously possess tailored degradation rates to match healing time, sufficient mechanical support for the duration of the healing process to prevent long-term recurrence and ensure space maintenance, and limited foreign body response to prevent pain and discomfort. Current commercially available barrier membranes fail to meet the need of the dental industry, leading to additional costs and unnecessary pain for patients


It has demonstrated to be an efficient method to control the porous structure, which in the case of periodontal regeneration would provide critical means to generate a tissue-specific membrane. Previous studies demonstrated the ability of electrospun nanofibers to prevent cell infiltration without limiting the diffusion of oxygen and nutrients, making electrospinning a promising method to manufacture barrier membranes. Noteworthy, the main principle of GBR and GTR procedures is to place a barrier membrane between epithelial tissue and bone or bone graft to prevent migration of the fast-proliferating epithelial cells into the defect site to be able to preserve a space for recruitment of bone forming cells into the periodontal defect.


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