TISSUE ENGINEERING SCAFFOLDS

Tissue engineering is an emerging multidisciplinary field that integrates engineering principles with biology and medicine with the goal of restoring or enhancing tissue or organ functions.

Matregenix can produce customized and highly tailored nanofibrous scaffolds for various tissue engineering applications.

Slide Nanofibrous Scaffold Nanoscale dimension mimics native tissue
Tunable tensile strength and elasticity
High porosity facilitates oxygen permeability and nutrient transport
Spatial interconnectivity help in tissue regeneration Tunable geometry Ability to incorporate therapeutic molecules

Tissue engineering is an emerging multidisciplinary field that integrates engineering principles with biology and medicine with the goal of restoring or enhancing tissue or organ functions.

In one approach, tissue engineering involves the expansion of cells ex vivo followed by seeding onto a biodegradable scaffold, which mimics the natural tissue architecture, prior to implantation. Ideally, these scaffolds should promote cellular adhesion, proliferation, and migration while having similar structure and mechanical properties to the tissue that they aim to replace.

The design and fabrication of biocompatible scaffolds are the core tasks of tissue engineering from a materials science perspective. Electrospinning has emerged as a promising technique for manufacturing fibrous scaffolds with a large surface area to volume ratio to mimic the topology of the native ECM. The electrospinning process has been regarded in literature as the most facile and versatile technique to fabricate tissue engineering scaffolds. The possibility of incorporating one or multiple bioactive factors is another advantage of the process.

References

Soliman et al. A multilayer scaffold design with spatial arrangement of cells to modulate esophageal tissue growth. Accepted 2018, Biomed Mater Res B. J Biomed Mater Res B. 2018, 0: 10.1002.

Soliman et al. Multiscale 3D Scaffolds for Soft Tissue Engineering via Multimodal Electrospinning. Acta Biomaterialia. 2010, 6: 1227-1237.

Soliman et al. Electrospun PET: PU Scaffolds for Vascular Tissue Engineering. IEEE-EMB ICABME-15.2015.

Soliman et al. Controlling the Porosity of Fibrous Scaffolds by Modulating the Fiber Diameter and Packing Density. J Biomed Mater Res A. 2011, 3: 566-574.

Garcia, L, Soliman, S, Francis, MP, et al. Workshop on the characterization of fiber‐based scaffolds: Challenges, progress, and future directions. J Biomed Mater Res. 2020; 108: 2063– 2072.

La Francesca, J.M. Aho, M. Barron, E.W. Blanco, S. Soliman, et al. Long-term Regeneration and Remodeling of the Pig Esophagus after Circumferential Resection using a Retrievable Synthetic Scaffold Carrying Autologous Cell. Nature Scientific Reports. 2018, 8.4123.

Hasan, S. Soliman et al. In Vitro Testing of a Tissue Engineering PCL-PLLA Heart Valve. Nature Scientific Reports. 2018, 8.8187.

Traversa, B. Mecheri, C. Mandoli, S. Soliman et al. Tuning Hierarchical Architecture of 3D Polymeric Scaffolds for Cardiac Tissue Engineering. J. Experimental Nanoscience. 2008, 2: 97-110.

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